Is there a Correlation between Electrocardiographic Changes and Sodium Valproate Toxicity? An Investigation of 196 Cases

Reversal of Electrocardiographic Sodium Channel Blockade Changes with Bicarbonate Therapy in a Pediatric Patient Post-Cardiopulmonary Arrest Secondary to Methadone Toxicity

Frequency of Sodium Valproate-Induced Hair Loss and Curly Hair

Sodium valproate has been widely used by man as an antiepileptic drug. Hair loss and curly hair is a rare side effect of sodium valproate. We have conducted a prospective clinical study in the Department of Neurology in Shafa Hospital, Kerman, Iran for ten years (1994-2004). All 211 epileptic patients in our study were given sodium valproate as a single drug treatment. During the course of ther...

Curcumin Ameliorates Sodium Valproate Induced Neurotoxicity through Suppressing Oxidative Stress and Preventing Mitochondrial Impairments

Background and purpose: Curcumin is a natural polyphenolic compound in turmeric (Curcuma longa). Curcumin has potent free radical scavenger and antioxidant properties that could significantly reduce oxidative damage. Oxidative stress and mitochondrial dysfunction contribute to valproate sodium induced tissue damage. This study investigated the protective effects of curcumin against valproate so...

مقایسه اثربخشی و عوارض سیناریزین با سدیم والپروات در کنترل سردرد میگرنی افراد 20 تا 50 ساله، بیمارستان سینا سال 83-1382

Background: Calcium-antagonists (CA) are heterogeneous group of drugs with different efficacy in migraine prophylaxis. Several studies have firmly demonstrated flunarizine (FLU), and verapamil as the proven calcium-antagonists for migraine prophylaxis. Cinnarizine (CIN), is another CA with less complications and less antihistaminic action. There is very few studies to show the effect of this dr...

An Investigation and Comparison of the Effect of Sodium Valproate on Electrophysiological Specificities of the Epileptic and Bipolar Patients

Objective: Patients with epilepsy and with bipolar mood disorder usually are treated with anticonvulsant drugs; and this is due to similar neurological, electrophysiological, and chemical mechanisms, by which both of the disorders can be described. However, these two types of disorders are classified differently under the titles of either neurological or psychiatric disorders. The aim of this ...